Effects of soman-induced seizures on different extracellular amino acid levels and on glutamate uptake in rat hippocampus.

@article{Lallement1991EffectsOS,
  title={Effects of soman-induced seizures on different extracellular amino acid levels and on glutamate uptake in rat hippocampus.},
  author={Guy Lallement and Pierre Carpentier and Am{\'e}lie Collet and I Pernot-Marino and Dominique Baubichon and G{\'e}rard Blanchet},
  journal={Brain research},
  year={1991},
  volume={563 1-2},
  pages={234-40}
}
Extracellular amino acid levels in CA3 and CA1 fields of rat hippocampus, an area highly sensitive to seizures, were determined by intracranial microdialysis during seizures induced by systemic administration of soman (o-1,2,2-trimethylpropyl methylphosphonofluoridate), a potent inhibitor of acetylcholinesterase. The glutamate uptake level was determined on another series of animals in hippocampus homogenates. An early and transient increase in the extracellular glutamate level occurred in CA3… CONTINUE READING

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