Effects of sodium stibogluconate on differentiation and proliferation of human myeloid leukemia cell lines in vitro

@article{Pathak2002EffectsOS,
  title={Effects of sodium stibogluconate on differentiation and proliferation of human myeloid leukemia cell lines in vitro},
  author={M. Pathak and X. Hu and T. Yi},
  journal={Leukemia},
  year={2002},
  volume={16},
  pages={2285-2291}
}
PTPases are key signaling molecules and targets for developing novel therapeutics. We have studied the in vitro biological activity of PTPase inhibitor sodium stibogluconate (SS) on differentiation and proliferation of myeloid leukemia cell lines (NB4, HL-60 and U937). SS (250 μg/ml, 6 days) induced 87% of NB4 cells to reduce nitroblue tetrazolium (NBT), in comparison to the 90% induced by ATRA (1 μM, 6 days). SS treatment of NB4 cells resulted in an increase of CD11b expression and of a… Expand
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