Effects of sodium-potassium pump inhibition and low sodium on membrane potential in cultured embryonic chick heart cells.

@article{Jacob1987EffectsOS,
  title={Effects of sodium-potassium pump inhibition and low sodium on membrane potential in cultured embryonic chick heart cells.},
  author={Ralph Jacob and Melvyn Lieberman and Elizabeth Murphy and David R. Piwnica-Worms},
  journal={The Journal of physiology},
  year={1987},
  volume={387},
  pages={549-66}
}
1. When the Na+-K+ pump of cultured embryonic chick heart cells was inhibited by addition of ouabain with or without removal of external K+, the membrane potential rapidly depolarized to -40 mV and the Na+ content approximately doubled within 3 min. 2. After this, exposure to an [Na+]o of 27 mM caused a fall in Na+ content, a gain in Ca2+ content and a… CONTINUE READING