Effects of sodium gradient manipulation upon cellular calcium, 45Ca fluxes and cellular sodium in the guinea-pig taenia coli.


1. Sucrose and choline were utilized as NaCl substitutes in order to investigate Na-Ca interactions in the smooth muscle of the guinea-pig taenia coli.2. Progressive substitution of NaCl by sucrose caused a progressive increase in cellular exchangeable Ca. This uptake, which amounted to about 300 mumole Ca/kg tissue upon total Na replacement, reached a… (More)


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