Effects of sodium channel block with mexiletine to reverse action potential prolongation in in vitro models of the long term QT syndrome.

@article{Sicouri1997EffectsOS,
  title={Effects of sodium channel block with mexiletine to reverse action potential prolongation in in vitro models of the long term QT syndrome.},
  author={Serge Sicouri and Daniel Antzelevitch and Cory R. Heilmann and Charles Antzelevitch},
  journal={Journal of cardiovascular electrophysiology},
  year={1997},
  volume={8 11},
  pages={1280-90}
}
INTRODUCTION Recent clinical studies have reported a greater effectiveness of sodium channel block with mexiletine to abbreviate the QT interval in patients with the chromosome 3 variant (SCN5A, LQT3) of the long QT syndrome (LQTS) than those with the chromosome 7 form of the disease (HERG, LQT2), suggesting the possibility of gene-specific therapy for the… CONTINUE READING