Effects of snuff on regional blood flow to the cheek and tongue of anesthetized dogs.

  title={Effects of snuff on regional blood flow to the cheek and tongue of anesthetized dogs.},
  author={Keith Huckabee and R T Barnes and A. G. Williams and W L Fan and H. Fred Downey},
  journal={Oral surgery, oral medicine, and oral pathology},
  volume={76 6},
Regional blood flow to the cheek and tongue of anesthetized dogs was measured before and after application of six different doses of snuff (3.12 to 100 mg/kg body weight) to the right cheek. Dose-independent vasodilation was observed at the site of application, whereas dose-dependent vasoconstriction was observed contralaterally. Aortic, central venous, and ventricular pressures were significantly increased (p < 0.05) at the higher doses. Plasma nicotine concentrations increased stepwise with… Expand
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  • The American journal of physiology
  • 1972
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Circadian exposure to nicotine and cardiovascular effects, including urinary catecholamine excretion, were similar for all forms of tobacco use and systemic absorption of nicotine, sodium, and carcinogenic chemicals from smokeless tobacco may cause or aggravate human illness in addition to the known adverse effects on the oral cavity. Expand
The data presented suggest that the prolonged application of snuff into the gingivobuccal groove is a factor in the instigation of squamous cell carcinoma at this site. Expand