Effects of snuff on regional blood flow to the cheek and tongue of anesthetized dogs.

@article{Huckabee1993EffectsOS,
  title={Effects of snuff on regional blood flow to the cheek and tongue of anesthetized dogs.},
  author={Keith Huckabee and R T Barnes and A. G. Williams and W L Fan and H. Fred Downey},
  journal={Oral surgery, oral medicine, and oral pathology},
  year={1993},
  volume={76 6},
  pages={
          729-35
        }
}
Regional blood flow to the cheek and tongue of anesthetized dogs was measured before and after application of six different doses of snuff (3.12 to 100 mg/kg body weight) to the right cheek. Dose-independent vasodilation was observed at the site of application, whereas dose-dependent vasoconstriction was observed contralaterally. Aortic, central venous, and ventricular pressures were significantly increased (p < 0.05) at the higher doses. Plasma nicotine concentrations increased stepwise with… Expand
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