Effects of snake venom polypeptides on central nervous system.

  title={Effects of snake venom polypeptides on central nervous system.},
  author={Alexey V. Osipov and Yuri N. Utkin},
  journal={Central nervous system agents in medicinal chemistry},
  volume={12 4},
  • A. Osipov, Y. Utkin
  • Published 30 November 2012
  • Biology
  • Central nervous system agents in medicinal chemistry
The nervous system is a primary target for animal venoms as the impairment of its function results in the fast and efficient immobilization or death of a prey. There are numerous evidences about effects of crude snake venoms or isolated toxins on peripheral nervous system. However, the data on their interactions with the central nervous system (CNS) are not abundant, as the blood-brain barrier (BBB) impedes penetration of these compounds into brain. This updated review presents the data about… 
Animal venom studies: Current benefits and future developments.
  • Y. Utkin
  • Biology
    World journal of biological chemistry
  • 2015
It is concluded that venoms contain a large number of individual components belonging to a limited number of structural types, often minor changes in the amino acid sequence give rise to new biological properties.
Venom-based biotoxins as potential analgesics
This review discusses venom-derived peptidergic biotoxins that are in preclinical stages or already in clinical trials, including promising results from preliminary in vitro studies, ongoing challenges and unmet needs.
Hypertensive encephalopathy with locked-in syndrome mimicking brain death: An unusual case of Krait envenomation with literature review.
Snakebite should be considered in the differential diagnosis of unexplained neuroparalysis and hypertension and envenomation should not be excluded by the absence of a history of snakebite or an identifiable bite mark.
Expanding the MiniAp‐4 BBB‐shuttle family: Evaluation of proline cis‐trans ratio as tool to fine‐tune transport
This work has studied the conformation of the proline residue of a range of MiniAp‐4 analogues by high‐field NMR techniques, with the aim of identifying whether there is a direct relation between the cis/trans population and arange of features, such as the capacity to transport molecules across a human‐based cellular model and stability in various media.
There is a possibility of employing PVOV in the treatment of depressive and chronic degenerative illnesses as a nonherbal and nonsynthetic alternative for patients not responding to the available therapy.
What kills everyone, gives a high for some-Recreational Snake Envenomation.
Priapism following a juvenile Russell’s viper bite: An unusual case report
This unusual case report may lead to further scientific research in order to improve the clinical understanding of the pathophysiology of envenomation due to Russell's viper bites and discover the possibilities of developing venom-based candidate molecules to treat sexual dysfunction in males and females.
Persistent anosmia and olfactory bulb atrophy after mulga (Pseudechis australis) snakebite