Effects of smoking on local delivery of controlled-release doxycycline as compared to scaling and root planing.

@article{Ryder1999EffectsOS,
  title={Effects of smoking on local delivery of controlled-release doxycycline as compared to scaling and root planing.},
  author={Mark I. Ryder and Bertrand Pons and Donald F Adams and Bradley B Beiswanger and Ver{\'o}nica Parra Blanco and Gary Bogle and Kevin J. Donly and William W Hallmon and Everett B Hancock and Philip J. Hanes and Charles Hawley and Liane B Johnson and H L Wang and Lawrence E. Wolinsky and Raymonda Yukna and Alan M Polson and Gilles Carron and Steve Garrett},
  journal={Journal of clinical periodontology},
  year={1999},
  volume={26 10},
  pages={683-91}
}
This paper examines the effects of smoking on the treatment outcomes of two nonsurgical therapies: (1) scaling and root planing alone (SRP) or (2) controlled-release of subgingivally delivered doxycycline hyclate in a polylactic acid based polymer gel. Subjects from 2 9-month multicenter studies were classified as nonsmokers (never smoked: 100 subjects), former smokers (137 subjects), and current smokers (> or = 10 cigarettes/day: 121 subjects). Clinical parameters were analyzed for treated… CONTINUE READING