Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson’s disease

Abstract

Alpha-synuclein (aS) amyloid formation is involved in Parkinson's disease (PD); therefore, small molecules that target aS and affect its aggregation are of interest as future drug candidates. We recently reported modified ring-fused 2-pyridones that modulate aS amyloid formation in vitro. Here, we describe the effects of such molecules on behavioral… (More)
DOI: 10.1371/journal.pone.0184117

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@inproceedings{Pokrzywa2017EffectsOS, title={Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson’s disease}, author={Małgorzata Pokrzywa and Katarzyna Pawełek and Weronika Elżbieta Kucia and Szymon Sarbak and Erik Chorell and Fredrik Almqvist and Pernilla Wittung-Stafshede}, booktitle={PloS one}, year={2017} }