Effects of small ischemic lesions in the primary motor cortex on neurophysiological organization in ventral premotor cortex.

@article{Dancause2006EffectsOS,
  title={Effects of small ischemic lesions in the primary motor cortex on neurophysiological organization in ventral premotor cortex.},
  author={Numa Dancause and Scott Barbay and Shawn B. Frost and Elena V. Zoubina and Erik J. Plautz and Jonathan D. Mahnken and Randolph J. Nudo},
  journal={Journal of neurophysiology},
  year={2006},
  volume={96 6},
  pages={
          3506-11
        }
}
After a cortical lesion, cortical areas distant from the site of injury are known to undergo physiological and anatomical changes. However, the mechanisms through which reorganization of distant cortical areas is initiated are poorly understood. In a previous publication, we showed that the ventral premotor cortex (PMv) undergoes physiological reorganization after a lesion destroying the majority of the primary motor cortex (M1) distal forelimb representation (DFL). After large lesions… Expand
The Effect of Lesion Size on the Organization of the Ipsilesional and Contralesional Motor Cortex
TLDR
The data show that lesion size has comparable effects on motor representations in premotor areas of both hemispheres and suggest that the contralesional premotor cortex may play a greater role in the recovery of the paretic forelimb following large lesions. Expand
The effect of lesion size on cortical reorganization in the ipsi and contralesional hemispheres
motrice la plus influencée dans le cortex contralésionnel. ABSTRACT While our understanding of ipsilesional plasticity and its role in recovery of hand function following ischemic stroke hasExpand
Plasticity in the motor network following primary motor cortex lesion.
  • N. Dancause
  • Medicine
  • Advances in experimental medicine and biology
  • 2013
TLDR
The basic principles of organization of the primary motor and premotor cortex are reviewed with the addition of a few key studies carried out in monkeys that have contributed to understandings of adaptive plasticity in the ipsilesional hemisphere after stroke. Expand
Long-term motor cortical map changes following unilateral lesion of the hand representation in the motor cortex in macaque monkeys showing functional recovery of hand functions.
TLDR
The degree of functional recovery is not related to a reorganization of motor maps within, and in the vicinity of, a M1 lesion, and post-lesion ICMS thresholds to elicit movements of forelimb muscle territories increased, independently from the degree offunctional recovery. Expand
Sensorimotor cortex injury effects on recovery of contralesional dexterous movements in Macaca mulatta
TLDR
Overall, these findings demonstrate that frontoparietal injury impairs hand motor function more so than frontal motor injury alone, and results in slower and poorer recovery than lesions limited to frontal motor cortex. Expand
Task Related Neural Activity Following Primary Motor Cortical Ischemic Injury in Rats
TLDR
The data suggest contralateral pre-motor and ipsilateral M1 alter their neural response profiles with respect to the timing of a motor task during recovery, the first demonstration of a compensatory single-spike neurophysiological mechanism that may explain how remote, spared cortical areas contribute to functional recovery after M1 injury. Expand
Evidence for a role of the reticulospinal system in recovery of skilled reaching after cortical stroke: initial results from a model of ischemic cortical injury
TLDR
The results are consistent with increased reliance on PMRF motor outputs for recovery of voluntary upper limb motor control after significant cortical ischemic injury. Expand
Remapping of the somatosensory cortex after a photothrombotic stroke: dynamics of the compensatory reorganization
TLDR
Spatial and temporal remodeling of the brain induced by cortical stroke, leading to vicariation of function is demonstrated and may become the basis for designing appropriate strategies of rehabilitation. Expand
Influence of anti-Nogo-A antibody treatment on the reorganization of callosal connectivity of the premotor cortical areas following unilateral lesion of primary motor cortex (M1) in adult macaque monkeys
TLDR
These results are consistent with a sprouting and/or sparing of callosal axons promoted by the anti-Nogo-A antibody treatment after lesion of the primary motor cortex, as compared to untreated monkeys. Expand
Corticocortical Connections of the Rostral Forelimb Area in Rats: A Quantitative Tract-Tracing Study
TLDR
Corticocortical connections of RFA in rat are strikingly similar to cortical connections of the ventral premotor cortex in non-human primates, suggesting that these areas share similar functions. Expand
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References

SHOWING 1-10 OF 36 REFERENCES
Reorganization of the human ipsilesional premotor cortex after stroke.
TLDR
Results indicate that PMdAH participates as a substrate mediating functional recovery of executive motor function in patients with focal lesions of corticospinal outflow originating in M1 and good motor recovery, consistent with the hypothesis that the dorsal premotor cortex of the affected hemisphere can reorganize to control basic parameters of movement usually assigned to M1 function. Expand
Reorganization of remote cortical regions after ischemic brain injury: a potential substrate for stroke recovery.
TLDR
It is suggested that neurophysiologic reorganization of remote cortical areas occurs in response to cortical injury and that the greater the damage to reciprocal intracortical pathways, the great the plasticity in intact areas. Expand
Reorganization of movement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys.
TLDR
It is concluded that substantial functional reorganization occurs in primary motor cortex of adult primates following a focal ischemic infarct, but at least in the absence of postinfarct training, the movements formerly represented in the infarCTed zone do not reappear in adjacent cortical regions. Expand
Dissociation of sensorimotor deficits after rostral versus caudal lesions in the primary motor cortex hand representation.
Primary motor cortex (M1) has traditionally been considered a motor structure. Although neurophysiologic studies have demonstrated that M1 is also influenced by somatosensory inputs (cutaneous andExpand
Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic Infarct
TLDR
The results suggest that, after local damage to the motor cortex, rehabilitative training can shape subsequent reorganization in the adjacent intact cortex, and that the undamaged motor cortex may play an important role in motor recovery. Expand
Mechanisms of recovery of dexterity following unilateral lesion of the sensorimotor cortex in adult monkeys
TLDR
It is suggested that PM plays a significant role in the incomplete functional recovery of hand dexterity following unilateral damage of the sensorimotor cortex in adult monkeys. Expand
Bi‐hemispheric contribution to functional motor recovery of the affected forelimb following focal ischemic brain injury in rats
TLDR
The data suggest that, in the rat, the undamaged (ipsilateral) motor system may contribute to compensatory recovery of the affected forelimb. Expand
Topographically divergent and convergent connectivity between premotor and primary motor cortex.
TLDR
It is found that PMv projections to M1 were not evenly distributed but rather were directed consistently to three domains within the rostro-lateral portion of M1. Expand
Progressive plastic changes in the hand representation of the primary motor cortex parallel incomplete recovery from a unilateral section of the corticospinal tract at cervical level in monkeys
TLDR
Observations indicate that the CS fibers spared by the lesion are not sufficient, at least in their pre-lesion condition, to control the motoneurones innervating the digit muscles and that the pathways conveying signals from the contralateral M1 underwent reorganization. Expand
Factors Contributing to Motor Impairment and Recovery after Stroke
TLDR
Results suggest that specific aspects of motor-map remodeling are expressions of adaptive mechanisms that underlie functional recovery after stroke, and suggest that the adaptive mechanisms underlying postinjury recovery differ in detail from those that operate in normal motor learning. Expand
...
1
2
3
4
...