Effects of sleep deprivation on sleep homeostasis and restoration during methadone-maintenance: a [31]P MRS brain imaging study.

@article{Trksak2010EffectsOS,
  title={Effects of sleep deprivation on sleep homeostasis and restoration during methadone-maintenance: a [31]P MRS brain imaging study.},
  author={George H. Trksak and J. Eric Jensen and David T. Plante and David M. Penetar and Wendy Tartarini and Melissa A. Maywalt and Michael Brendel and Cynthia M. Dorsey and Perry F. Renshaw and Scott E. Lukas},
  journal={Drug and alcohol dependence},
  year={2010},
  volume={106 2-3},
  pages={79-91}
}
Insomnia afflicts many individuals, but particularly those in chronic methadone treatment. Studies examining sleep deprivation (SD) have begun to identify sleep restoration processes involving brain bioenergetics. The technique ([31])P magnetic resonance spectroscopy (MRS) can measure brain changes in the high-energy phosphates: alpha-, beta-, and gamma-nucleoside triphosphate (NTP). In the present study, 21 methadone-maintained (MM) and 16 control participants underwent baseline (BL), SD (40… CONTINUE READING

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