Effects of sleep deprivation in neonatal rats.

  title={Effects of sleep deprivation in neonatal rats.},
  author={Marcos Gabriel Frank and Roger N. Morrissette and H. Craig Heller},
  journal={The American journal of physiology},
  volume={275 1},
This investigation represents the first systematic study of sleep homeostasis in developing mammals that spans the preweaning and postweaning periods. Neonatal rats from 12 to 24 days of postnatal life (P12-P24) were anesthetized with Metofane (methoxyflurane) and implanted with miniaturized electroencephalographic (EEG) and electromyographic electrodes. After 48 h of recovery, neonatal rats were sleep deprived for 3 h by either gentle handling or forced locomotion. We find that 3-h sleep… CONTINUE READING

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