Effects of site-directed mutagenesis of basic residues (Arg 94, Lys 95, Lys 99) of lipopolysaccharide (LPS)-binding protein on binding and transfer of LPS and subsequent immune cell activation.

Abstract

LPS-binding protein (LBP) is a 60-kDa acute phase glycoprotein capable of binding the LPS of Gram-negative bacteria and facilitating its diffusion. This process is thought to be of potential importance in inflammatory reactions and pathogenic states such as septic shock syndrome. Here, we report on the identification of a LPS binding domain within the LBP… (More)

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@article{Lamping1996EffectsOS, title={Effects of site-directed mutagenesis of basic residues (Arg 94, Lys 95, Lys 99) of lipopolysaccharide (LPS)-binding protein on binding and transfer of LPS and subsequent immune cell activation.}, author={Norbert Lamping and Adolf Hoess and Bomina Yu and Tae Churl Park and Carsten J Kirschning and Darci Pfeil and Dajana Reuter and Sam D Wright and Friedhelm Herrmann and Ralf Schumann}, journal={Journal of immunology}, year={1996}, volume={157 10}, pages={4648-56} }