Effects of single nucleotide polymorphisms on treatment outcomes and toxicity in patients treated with sunitinib.

@article{Maeng2013EffectsOS,
  title={Effects of single nucleotide polymorphisms on treatment outcomes and toxicity in patients treated with sunitinib.},
  author={Chi Hoon Maeng and Jun Ho Yi and Jeeyun Lee and Jung Yong Hong and Moon Ki Choi and Hyun Ae Jung and Joon Oh Park and Se Hoon Park and Yong Seog Park and Won Ki Kang and Ho-yeong Lim},
  journal={Anticancer research},
  year={2013},
  volume={33 10},
  pages={4619-26}
}
BACKGROUND/AIM We analyzed the efficacy and toxicity profile of sunitinib according to single nucleotide polymorphisms (SNPs) of vascular endothelial growth factor receptor (VEGFR) and Kinase insert domain receptor (KDR). PATIENTS AND METHODS We examined eight known SNPs of VEGFA and five SNPs of KDR among patients with gastric or biliary tract cancer who were treated with sunitinib. We retrospectively assessed clinical outcomes and their relationships to these SNPs. RESULTS A total of 63… CONTINUE READING