Effects of single doses and daily administration of pyrithioxine (pyritinolum,NFN, RINN) on the alcohol withdrawal syndrome in rats.

@article{Hillbom1975EffectsOS,
  title={Effects of single doses and daily administration of pyrithioxine (pyritinolum,NFN, RINN) on the alcohol withdrawal syndrome in rats.},
  author={M. Hillbom and A. L. Kosunen and P. Nikander and A. P{\"o}s{\"o}},
  journal={Acta pharmacologica et toxicologica},
  year={1975},
  volume={36 Suppl 5},
  pages={
          427-40
        }
}
  • M. Hillbom, A. L. Kosunen, +1 author A. Pösö
  • Published 1975
  • Medicine
  • Acta pharmacologica et toxicologica
  • Male Wistar rats were made physically dependent on ethanol by intragastric administration (4-10 g/kg/day) for 20 days. The dose of ethanol was adjusted to maintain the maximal level of intoxication compatible with adequate intake of a liquid diet. After withdrawal of ethanol a few animals developed spontaneous tonic-clonic convulsions. A marked increase in susceptibility to sound-induced convulsions and decrease in sensitivity to pain were observed in the rats after withdrawal, and their serum… CONTINUE READING
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