Effects of single chemotherapeutic agents on development of urinary bladder tumor induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in rats

@article{Babaya1987EffectsOS,
  title={Effects of single chemotherapeutic agents on development of urinary bladder tumor induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in rats},
  author={Katsuhiro Babaya and Sh. Takahashi and Hitoshi Momose and Hisashi Matsuki and Kenichi Sasaki and Shoji Samma and Seiichiro Ozono and Yoshihiko Hirao and Eigoro Okajima},
  journal={Urological Research},
  year={1987},
  volume={15},
  pages={329-334}
}
Chemotherapeutic agents were evaluated for effect on the development of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in male Wistar strain rats. Seven hundred and two rats were given 0.05% BBN in drinking water for 8 weeks. After BBN treatment, the animals were divided into 26 groups to follow regimens of single chemotherapy. All drugs were administered intraperitoneally except in one group that was treated orally. In our experimental series, 5-fluorouracil (5… CONTINUE READING
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