Effects of single and repeated doses of omeprazole on gastric acid and pepsin secretion in man.

Abstract

The effects of omeprazole, a substituted benzimidazole, on gastric acid and pepsin secretion have been studied in twelve healthy subjects. From six to eight hours after a single oral dose of 30 mg, there was a 66% reduction in basal acid output, and a 71.2% reduction in pentagastrin stimulated acid output. A single dose of 60 mg produced a 91.7% reduction… (More)

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@article{Howden1984EffectsOS, title={Effects of single and repeated doses of omeprazole on gastric acid and pepsin secretion in man.}, author={Chris Howden and James A. Forrest and J. Leighton Reid}, journal={Gut}, year={1984}, volume={25 7}, pages={707-10} }