Effects of single and combined metformin and l-citrulline supplementation on l-arginine-related pathways in Becker muscular dystrophy patients: possible biochemical and clinical implications

@article{Hanff2018EffectsOS,
  title={Effects of single and combined metformin and l-citrulline supplementation on l-arginine-related pathways in Becker muscular dystrophy patients: possible biochemical and clinical implications},
  author={Erik Hanff and P. Hafner and A. Bollenbach and U. Bonati and A. A. Kayacelebi and D. Fischer and D. Tsikas},
  journal={Amino Acids},
  year={2018},
  volume={50},
  pages={1391-1406}
}
The l-arginine/nitric oxide synthase (NOS) pathway is considered to be altered in muscular dystrophy such as Becker muscular dystrophy (BMD. [...] Key Method We also investigated the combined use of l-citrulline (3 × 5 g/d) and metformin (3 × 500 mg/d). Before and after treatment, we measured in serum and urine samples the concentration of amino acids and metabolites of l-arginine-related pathways and the oxidative stress biomarker malondialdehyde (MDA). Compared to healthy subjects, BMD patients have altered…Expand
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