Effects of single and chronic treatment with tranylcypromine on extracellular serotonin in rat brain.

@article{Ferrer1994EffectsOS,
  title={Effects of single and chronic treatment with tranylcypromine on extracellular serotonin in rat brain.},
  author={Ana Ferrer and Francesc Casa{\~n}as Artigas},
  journal={European journal of pharmacology},
  year={1994},
  volume={263 3},
  pages={227-34}
}
We have examined the effects of tranylcypromine, a monoamine oxidase inhibitor used as antidepressant, on the tissue and extracellular concentration of serotonin (5-hydroxytryptamine, 5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in frontal cortex and dorsal raphe nucleus using microdialysis in conscious rats. Single treatment with tranylcypromine sulphate (0.5, 3 and 15 mg/kg, i.p.) dose dependently elevated dialysate 5-HT in both areas but more markedly in the DRN. Extracellular and tissue 5… CONTINUE READING