Effects of sinefungin and S-adenosylhomocysteine on DNA and protein methyltransferases from Streptomyces and other bacteria.

@article{Barbs1990EffectsOS,
  title={Effects of sinefungin and S-adenosylhomocysteine on DNA and protein methyltransferases from Streptomyces and other bacteria.},
  author={Covadonga Barb{\'e}s and Jes{\'u}s Salinas S{\'a}nchez and Mar{\'i}a Jes{\'u}s Yebra and Malka Robert-Gero and Carlos Hardisson},
  journal={FEMS microbiology letters},
  year={1990},
  volume={57 3},
  pages={
          239-43
        }
}
Sinefungin is a naturally occurring nucleoside isolated from cultures of Streptomyces griseolus and S. incarnatus. It is structurally related to S-adenosyl-methionine (SAM) and S-adenosyl-L-homocysteine (SAH). Its effect and level of action on prokaryotes has not been studied with the same detail as with eukaryotic cells. In this report we describe the effect of sinefungin and SAH on several Streptomyces methyltransferases (DNA and protein MTases) and on other bacterial DNA-MTases. Protein… CONTINUE READING