Effects of simvastatin gels on murine calvarial bone.

  title={Effects of simvastatin gels on murine calvarial bone.},
  author={Michael R. Thylin and Jay C McConnell and Marian J Schmid and Ryon R Reckling and Junu Ojha and Indraneel B Bhattacharyya and David B. Marx and Richard A. Reinhardt},
  journal={Journal of periodontology},
  volume={73 10},
BACKGROUND The cholesterol-lowering drug simvastatin has been shown to stimulate murine calvarial bone growth after multiple injections. The purpose of this study was to test if similar bone stimulation could be induced by 2 single-dose drug delivery systems appropriate to periodontal therapy. METHODS ICR Swiss mice were treated with the following protocols: 1) injection of methylcellulose gel alone, subcutaneously over the calvarium (INJ-GEL; n = 8); 2) injection of gel with simvastatin (INJ… CONTINUE READING


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