Effects of simvastatin and cholestyramine in familial and nonfamilial hypercholesterolemia. Multicenter Group I.

@article{Stein1990EffectsOS,
  title={Effects of simvastatin and cholestyramine in familial and nonfamilial hypercholesterolemia. Multicenter Group I.},
  author={Evan A. Stein and R V Kreisberg and Valery Miller and G E Mantell and L W Washington and Deborah R Shapiro},
  journal={Archives of internal medicine},
  year={1990},
  volume={150 2},
  pages={341-5}
}
Simvastatin, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, was compared with cholestyramine resin in a randomized open-label 12-week multicenter study of 251 high-risk patients with familial or nonfamilial hypercholesterolemia. Simvastatin, 20 mg and 40 mg daily, produced mean reductions in total cholesterol of 26% and 33… CONTINUE READING