Effects of silver nanoparticles on the liver and hepatocytes in vitro.

@article{Gaiser2013EffectsOS,
  title={Effects of silver nanoparticles on the liver and hepatocytes in vitro.},
  author={Birgit K Gaiser and Stephanie Hirn and Ali Kermanizadeh and Nilesh Kanase and Kleanthis Fytianos and Alexander Wenk and Nadine Haberl and Andrea Brunelli and Wolfgang G. Kreyling and Vicki Stone},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2013},
  volume={131 2},
  pages={
          537-47
        }
}
  • B. Gaiser, Stephanie Hirn, +7 authors V. Stone
  • Published 1 February 2013
  • Biology, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
With the increasing use and incorporation of nanoparticles (NPs) into consumer products, screening for potential toxicity is necessary to ensure customer safety. NPs have been shown to translocate to the bloodstream following inhalation and ingestion, and such studies demonstrate that the liver is an important organ for accumulation. Silver (Ag) NPs are highly relevant for human exposure due to their use in food contact materials, dietary supplements, and antibacterial wound treatments. Due to… 
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128 Citations

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Treatment with either AgNP or Ag ions resulted in membrane damage and reduced the cell function of human liver cells, and oxidative stress markers indicated that oxidative stress might contribute to the toxicity effects of nano and ionic forms of silver.
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The present review discusses the current advances on the physiochemical properties of AgNPs with specific emphasis on biodistribution and both in vitro and in vivo toxicity following various routes of exposure.
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Physiologically based pharmacokinetic models for gold/dendrimer composite nanodevices, AgNPs, and TiO2 NP models have been developed in rats and extrapolated to humans to support risk assessment and nanomedicine applications.
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