Effects of sildenafil on myocardial infarct size, microvascular function, and acute ischemic left ventricular dilation.

@article{Reffelmann2003EffectsOS,
  title={Effects of sildenafil on myocardial infarct size, microvascular function, and acute ischemic left ventricular dilation.},
  author={Thorsten Reffelmann and Robert A. Kloner},
  journal={Cardiovascular research},
  year={2003},
  volume={59 2},
  pages={441-9}
}
OBJECTIVE Adverse cardiac events in patients treated with the phosphodiesterase-5 inhibitor sildenafil for erectile dysfunction raised concerns about its safety in ischemic heart disease. METHODS In anesthetized open-chest rabbits, receiving 1.45 mg/kg sildenafil intravenously or saline 30 min prior to ischemia (n=12, each), infarct size (IS, triphenyltetrazolium), the area of no-reflow (ANR, thioflavin S) (% of the risk area, RA, blue dye), and regional myocardial blood flow (RMBF… CONTINUE READING
19 Citations
23 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 23 references

Tissue distribution

  • RM W allis, JD Corbin, SH Francis, P. Ellis
  • Br J Pharmacol
  • 2002
Highly Influential
3 Excerpts

Cardiac electrophysiologic and myocardial infarction associated with sildenafil

  • J Feenstra, van Drie-Pierik RJHM, CF Lacle, Stricker BHCH, Y Satoh, H Shiina
  • J Cardiovasc Pharmacol
  • 2002

Effects of sildenafil on cAMP expected deaths in sildenafil ( viagra ) users

  • DK Wysowski, E Farinas, L Swartz, S Uckert, AJ Becker
  • Am J Cardiol and cGMP levels in isolated human…
  • 2002

Nitric oxide inhibits the study of arterial risk factors in 440 impotent men . Lancet positive inotropic response to beta - adrenergic stimulation in humans

  • R Virag, P Bouilly, D Frydman, E Loh, MA Creager, WS Coluci
  • 2002

Similar Papers

Loading similar papers…