Effects of sildenafil on cAMP and cGMP levels in isolated human cavernous and cardiac tissue.

@article{Stief2000EffectsOS,
  title={Effects of sildenafil on cAMP and cGMP levels in isolated human cavernous and cardiac tissue.},
  author={Christian G Stief and Stefan Uckert and Armin J. Becker and Wolfgang Harringer and Michael C. Truss and Wolf Georg Forssmann and Udo Jonas},
  journal={Urology},
  year={2000},
  volume={55 1},
  pages={146-50}
}
OBJECTIVES To further investigate the mechanism of action of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase 5 (PDE5), that has been proved to be effective in the treatment of male erectile dysfunction. We assessed the effects of sildenafil on the in vitro formation of cGMP and cyclic adenosine monophosphate (cAMP) in isolated human corpus cavernosum and cardiac muscle. METHODS Isolated segments of human corpus cavernosum and cardiac… CONTINUE READING

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