Effects of short-term oral salbutamol administration on exercise endurance and metabolism.

@article{Collomp2000EffectsOS,
  title={Effects of short-term oral salbutamol administration on exercise endurance and metabolism.},
  author={Katia Collomp and Robin Candau and Françoise Lasne and Zakaria Labsy and Christian G. Prefaut and Jacques de Ceaurriz},
  journal={Journal of applied physiology},
  year={2000},
  volume={89 2},
  pages={
          430-6
        }
}
The present study examined whether oral short-term administration of salbutamol (Sal) modifies performance and selected hormonal and metabolic variables during submaximal exercise. Eight recreational male athletes completed two cycling trials at 80-85% peak O(2) consumption until exhaustion after either gelatin placebo (Pla) or oral Sal (12 mg/day for 3 wk) treatment, according to a double-blind and randomized protocol. Blood samples were collected at rest, after 5, 10, and 15 min, and at… 
Salbutamol intake and substrate oxidation during submaximal exercise
TLDR
The theory that the ergogenic effect of salbutamol results from a change in substrate oxidation has little support during relatively short term endurance exercise, but it is conceivable that longer exercise duration can generate positive findings.
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TLDR
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TLDR
Salbutamol induced significant improvement in calf muscle endurance with similar metabolic responses during exercise, except slight differences in pHi, and other mechanisms than changes in muscle metabolism may be responsible for the ergogenic effect of salbutamole administration.
Effect of salbutamol on neuromuscular function in endurance athletes.
TLDR
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Acute supra-therapeutic oral terbutaline administration has no ergogenic effect in non-asthmatic athletes
TLDR
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Acute impact of inhaled short acting b2-agonists on 5 km running performance.
TLDR
There was no improvement in 5 km time-trial performance following the inhalation of up to 1600 µg of salbutamol in non-asthmatic athletes, which would suggest that the current WADA guidelines, which allow athletes to inhale up to1600 µg per day, is sufficient to avoid pharmaceutical induced performance enhancement.
THE EFFECTS OF ACUTE INHALED SALBUTAMOL ON POWER OUTPUT AND BLOOD LACTATE CONCENTRATION IN NONASTHMATIC ELITE KUNG FU ATHLETES
TLDR
In conclusion, administering a single inhaled (400 μg) of the β2-adrenergic agonist Salbutamol to healthy, elite anaerobic trained male athletes has no ergogenic effect.
Effects of β2-adrenergic stimulation on exercise capacity in normal subjects
TLDR
The acute administration of either low or high dose salbutamol does not affect exercise capacity in normal subjects, in spite of an earlier anaerobic threshold and increased chemosensitivity.
Clenbuterol diminishes aerobic performance in horses.
TLDR
It is suggested that the combined effect of therapeutic levels of clenbuterol and training decrease aerobic performance and that the resultant reduction in plasma volume may affect improvements in cardiovascular function during recovery normally seen with exercise training.
Ergogenic Effects of Intake of Salbutamol, Caffeine and Theobromine on Non-Asthmatic Subjects
TLDR
Overall, salbutamol, the intake of which is restricted by WADA, did not have an ergogenic effect on athletes, while caffeine and theobromine, the usage of which are not controlled at all in sports competitions, had a performance enhancing effect on Athletes, according to the results.
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References

SHOWING 1-10 OF 40 REFERENCES
Effects of oral albuterol on serum lipids and carbohydrate metabolism in healthy men.
TLDR
Albuterol administration was associated with favorable changes in the serum lipid profile without marked impairment of glucose tolerance or its physiologic determinants.
The effect of salbutamol on performance in elite nonasthmatic athletes.
TLDR
It was concluded that a therapeutic dose of aerosol salbutamol does not have an ergogenic effect in elite nonasthmatic athletes, and it is therefore recommended that inhaled sal butamol continue to be permitted in international competition for individuals with exercise induced bronchospasm.
Short- and long-term effect of oral salbutamol on growth hormone secretion in prepubertal asthmatic children.
TLDR
The data suggest an inhibition of both spontaneous and stimulated GH secretion following short-term oral salbutamol ingestion, but this suppressive effect is not maintained with its long-term use.
Salbutamol and treadmill performance in non-atopic athletes.
TLDR
The results indicate that therapeutic administration of a selective beta-2 agonist does not affect pulmonary function or performance-related variables in non-atopic elite athletes.
Effect of two β2-agonist drugs, salbutamol and broxaterol, on the growth hormone response to exercise in adult patients with asthmatic bronchitis
TLDR
It is demonstrated for the first time that β2 stimulation blunts the physiological GH response to maximal exercise in adult human subjects and it can be suggested that changes in brain neurotransmitters, possibly an increase in the alpha-adrenergic tone, are likely to be involved in this endocrine effects of exercise.
Influence of caffeine and carbohydrate feedings on endurance performance.
TLDR
Data demonstrate an enhanced rate of lipid catabolism and work production following the ingestion of caffeine, and fat oxidation was elevated 31% and appeared to provide the substrate needed for the increased work production during this period of exercise.
Effects of caffeine ingestion on metabolism and exercise performance.
TLDR
The enhanced endurance performance observed in the C Trial was likely the combined effects of caffeine on lipolysis and its positive influence on nerve impulse transmission.
Salbutamol, a beta 2-adrenoceptor agonist, increases skeletal muscle strength in young men.
TLDR
It is demonstrated that short-term administration of salbutamol increases voluntary muscle strength in man, however, the magnitude and duration of this effect vary between muscle groups.
The effects of albuterol and isokinetic exercise on the quadriceps muscle group.
TLDR
Results indicate therapeutic doses of albuterol administered with resistance exercise may augment strength gains, and MANOVA and the Dunn-Bonferroni post-hoc found differences within groups for CPT, CTW, CAP, CPR/BW, EPT, ETTPT, and CSA.
Therapeutical doses of salbutamol inhibit the somatotropic responsiveness to growth hormone-releasing hormone in asthmatic children
TLDR
Data show that in asthmatic children, therapeutical doses of SAL exert a marked inhibitory effect on GH secretion, and further studies are needed to exclude detrimental effects of chronic treatment with β2-agonists onGH secretion and growth velocity.
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