Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production.

@article{Bevilacqua2004EffectsOS,
  title={Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production.},
  author={Lisa Bevilacqua and Jon Ramsey and Kevork Hagopian and Richard Weindruch and Mr. W. H. Harper},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2004},
  volume={286 5},
  pages={E852-61}
}
Reductions in cellular oxygen consumption (Vo2) and reactive oxygen species (ROS) production have been proposed as mechanisms underlying the anti-aging effects of calorie restriction (CR). Mitochondria are a cell's greatest "sink" for oxygen and also its primary source of ROS. The mitochondrial proton leak pathway is responsible for 20-30% of Vo2 in resting cells. We hypothesized that CR leads to decreased proton leak with consequential decreases in Vo2, ROS production, and cellular damage… CONTINUE READING

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Effect of time of restriction on the decrease in mitochondrial H2O2 production and oxidative DNA damage in the heart of food-restricted rats

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