Effects of short and long duration hypothyroidism and hyperthyroidism on the plasma adrenocorticotropin and corticosterone responses to ovine corticotropin-releasing hormone in rats.

@article{Kamilaris1991EffectsOS,
  title={Effects of short and long duration hypothyroidism and hyperthyroidism on the plasma adrenocorticotropin and corticosterone responses to ovine corticotropin-releasing hormone in rats.},
  author={Themis Kamilaris and C R Debold and Elizabeth Ourania Johnson and Evagelia Mamalaki and Samuel J Listwak and Aldo E Calogero and K T Kalogeras and Philip W. Gold and David N. Orth},
  journal={Endocrinology},
  year={1991},
  volume={128 5},
  pages={2567-76}
}
We report here a study of the plasma ACTH and corticosterone responses to synthetic ovine CRH (oCRH) in hypothyroid and hyperthyroid rats studied 7, 15, and 60 days after either thyroidectomy or the administration of pharmacological doses of T4. The purpose of this study was to further clarify the time-dependent effects of alterations in thyroid status on the functional integrity of the hypothalamic-pituitary-adrenal axis and to aid in the interpretation of the oCRH stimulation test in hypo… CONTINUE READING
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