Effects of short‐term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo‐controlled trial

@article{Wulffel2003EffectsOS,
  title={Effects of short‐term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo‐controlled trial},
  author={Michiel G Wulffel{\'e} and Adriaan Kooy and Philippe Lehert and Dani{\"e}l Bets and J. C. Ogterop and B. Burg and Ab J. M. Donker and Coen D. A. Stehouwer},
  journal={Journal of Internal Medicine},
  year={2003},
  volume={254}
}
Abstract.  Wulffelé MG, Kooy A, Lehert P, Bets D, Ogterop JC, Borger van der Burg B, Donker AJM, Stehouwer CDA (Bethesda General Hospital, Hoogeveen, The Netherlands; University of Mons, Mons, Belgium; Merck Nederland B.V., Amsterdam; Deaconesses’ Hospital, Meppel; Aleida Kramer Hospital, Coevorden; and Vrije Universiteit Medical Centre, Amsterdam; The Netherlands). Effects of short‐term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes… Expand
Effect of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.
TLDR
The Effect of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus is addressed and compared. Expand
Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial
TLDR
Long term treatment with metformin increases the risk of vitamin B-12 deficiency, which results in raised homocysteine concentrations, therefore, the findings suggest that regular measurement of vitaminB-12 concentrations during long term met formin treatment should be strongly considered. Expand
Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin B12 in patients with type 2 diabetes mellitus.
TLDR
In patients with type 2 diabetes, metformin reduces levels of folate and vitamin B(12) and increases Hcy, Conversely, rosiglitazone decreases Hcy levels in this time period. Expand
Adverse effect of metformin therapy on serum vitamin B12 and folate: short-term treatment causes disadvantages?
TLDR
It is postulate that even a few-month treatment with metformin results in the decrease of vitamin B12 and folate, and supplementation of Vitamin B12 rather than the combination of vitaminB12 and Folate might be profitable based on the mechanism of metformIn on vitamins in patients with type 2 diabetes. Expand
Effects of Metformin With or Without Supplementation With Folate on Homocysteine Levels and Vascular Endothelium of Women With Polycystic Ovary Syndrome
TLDR
Metformin exerts a slight but significant deleterious effect on serum Hcy levels in patients with PCOS, and supplementation with folate is useful to increase the beneficial effect of metformin on the vascular endothelium. Expand
Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post hoc analysis of a randomized controlled 4.3year trial.
TLDR
Metformin not only reduces serum levels of B12, but also progressively increases serum MMA, a biomarker for tissue B12 deficiency, and the increase of MMA in metformin users was associated with significant worsening of the NPS. Expand
Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia.
TLDR
Folate and vitamin B12 treatment improved insulin resistance and endothelial dysfunction, along with decreasing homocysteine levels, in patients with metabolic syndrome, suggesting that folic acid has several beneficial effects on cardiovascular disease risk factors. Expand
Effects of short‐term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo‐controlled trial
TLDR
Data on this issue are scarce and it is tested, in the setting of a randomized, placebo‐controlled trial, whether metformin can affect endothelial function and low‐grade inflammation. Expand
Vitamin B12 and folate concentrations in recent-onset type 2 diabetes and the effect of metformin treatment.
TLDR
Metformin does not affect circulating holoTC and folate concentrations in recent-onset type 2 diabetes, rendering monitoring of vitamin B12 and folates dispensable at least during the first 6 months after diagnosis or initiation of metformin. Expand
The Effect of Metformin Treatment on the Serum Levels of Homocysteine, Folic Acid, and Vitamin B12 in Patients with Polycystic Ovary Syndrome
TLDR
Findings indicate that metformin increases the serum Hcy concentration in patients with PCOS especially in the women with BMI’s above 25kg/m2, and the possible mechanism for this effect would be the obvious reduction in the levels of vit B12. Expand
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