Effects of shilajit on the bone tissue of alcohol administered rats

  title={Effects of shilajit on the bone tissue of alcohol administered rats},
  author={Payal Bhardwaj and Mehak Goel and Durg Vijay Rai},
Pharmacogenetics and pharmacogenomics are two major emerging trends in medical sciences, which influence the success of drug development and therapeutics. In current times, though pharmacogenetic studies are being done extensively for research, its application for drug development needs to get started on a large scale. Pharmacogenetic studies can be used at various stages of drug development. The effect of drug target polymorphisms on drug response can be assessed and identified. In clinical… 

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The decrease in the levels of the gonadal hormones and the increase of cortisol, observed in chronic alcoholics, may indirectly cause osteopenia and aseptic necrosis, all of which influence bone changes and increase the incidence of bone fractures.

Alcohol and bone

The etiology of alcohol-associated bone disease is multifactorial, and independent of whether alcohol consumption is of short duration, social, or heavy and chronic, it seems to suppress the function of osteoblasts, as evidenced by low serum levels of osteocalcin.

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Findings suggested that alcohol detoxification is highly suggested in pre-operative planning and this corroborates to the success of bone surgery and bone tissue repair.

Alcohol’s Harmful Effects on Bone

Some evidence suggests that moderate drinking may decrease the risk of fracture in postmenopausal women, and alcohol consumption during adolescence reduces peak bone mass and can result in relatively weak adult bones that are more susceptible to fracture.

Zinc as a nutritional approach to bone loss prevention in an ovariectomized rat model

Findings suggest that changes in cortical bone attributed to estrogen deficiency are arrested by zinc supplementation, which can be a sustainable approach to improving bone health.

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The objectives of this review are to identify the characteristics of alcohol-induced bone loss and deficient bone repair as revealed in human and animal studies, and to determine the current understanding of the cellular effects underlying both skeletal abnormalities, to suggest directions for future studies to resolve current ambiguities.

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Catalysis of peroxidation of unsaturated fatty acids by the mitochondrial and microsomal fractions of liver is inhibited by ascorbic acid at pH7.4 but the activity of the supernatant fraction is enhanced.