Effects of sex steroid hormones and their metabolites on neuronal injury caused by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal slice cultures

@article{Ishihara2016EffectsOS,
  title={Effects of sex steroid hormones and their metabolites on neuronal injury caused by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal slice cultures},
  author={Y. Ishihara and Noriko Fujitani and H. Sakurai and T. Takemoto and Takeshi Yamazaki},
  journal={Steroids},
  year={2016},
  volume={113},
  pages={71-77}
}
  • Y. Ishihara, Noriko Fujitani, +2 authors Takeshi Yamazaki
  • Published 2016
  • Chemistry, Medicine
  • Steroids
  • In this study, protective actions of the sex steroid hormones, progesterone, testosterone, and 17β-estradiol, against oxygen-glucose deprivation (OGD)/reoxygenation-induced neuronal cell death were examined using rat organotypic hippocampal slice cultures. Progesterone, testosterone, and 17β-estradiol significantly attenuated neuronal cell death elicited by OGD/reoxygenation. While the neuroprotection conferred by progesterone was not affected by SU-10603, an inhibitor of cytochrome P45017… CONTINUE READING
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