Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635.

@article{Parsey2002EffectsOS,
  title={Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635.},
  author={Ramin V. Parsey and Maria A. Oquendo and Norman Ray Simpson and R. Todd Ogden and Ronald L van Heertum and Victoria Arango and J. John Mann},
  journal={Brain research},
  year={2002},
  volume={954 2},
  pages={173-82}
}
Serotonin (5-HT) 1A receptors have been implicated in a variety of conditions including, depression, suicidal behavior, and aggression. Post-mortem brain studies and in vivo imaging studies report a variety of age and sex effects on brain 5-HT(1A) binding. Behavioral data from 5-HT(1A) specific pharmacological challenges suggest a role for 5-HT(1A) receptors in aggression. The goal of the present study was to determine age, sex, and severity of life-time aggression effects on 5-HT(1A) binding… CONTINUE READING

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