Effects of several tricyclic antidepressants on the hemodynamics and myocardial contractility of the anesthetized dogs.

@article{Jandhyala1977EffectsOS,
  title={Effects of several tricyclic antidepressants on the hemodynamics and myocardial contractility of the anesthetized dogs.},
  author={Bhagavan S. Jandhyala and Marie L. Steenberg and James M. Perel and Albert A. Manian and Joseph P. Buckley},
  journal={European journal of pharmacology},
  year={1977},
  volume={42 4},
  pages={
          403-10
        }
}
Cardiovascular effects of several imipramine analogs were investigated in the anesthetized mongrel dogs. Significant reduction in the cardiac output produced by lower doses (2.5 mg/kg, i.v.) of imipramine and 2-OH-DMI was not due to a depression of myocardial contractility. In contrast, 2-OH-imipramine (1.25 mg/kg) and DMI (2.5 mg/kg) significantly reduced contractility within 10 min after i.v. administration; however, significant decrease in the cardiac output did not occur until after 60 min… CONTINUE READING

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