Effects of several benzodiazepines, alone and in combination with flumazenil, in rhesus monkeys trained to discriminate pentobarbital from saline

  title={Effects of several benzodiazepines, alone and in combination with flumazenil, in rhesus monkeys trained to discriminate pentobarbital from saline},
  author={William L. Woolverton and Michael A. Nader},
The purpose of the present study was to further investigate the relationship between the DS effects of PB and those of benzodiazepines (BZs) and to begin to collect pharmacological information concerning receptor mechanisms involved in this behavioral effect of BZs. Rhesus monkeys (n=3), trained to discriminate pentobarbital (PB; 10 mg/kg, IG) from saline under a discrete-trials shock avoidance procedure, were given IG diazepam (0.3–10 mg/kg), chlordiazepoxide (1.0–30 mg/kg), or etizolam (0.3… 

Antagonism of the Ethanol-Like Discriminative Stimulus Effects of Ethanol, Pentobarbital, and Midazolam in Cynomolgus Monkeys Reveals Involvement of Specific GABAA Receptor Subtypes

GABAA receptors with high affinity for Ro15-4513 (i.e., containing α4/6 and α5 subunits) may be particularly important mediators of the multiple discriminative stimulus effects of ethanol through GABAA receptor systems.

Carisoprodol-Mediated Modulation of GABAA Receptors: In Vitro and in Vivo Studies

The results of these studies in vivo and in vitro collectively suggest the barbiturate-like effects of carisoprodol may not be due solely to its metabolite, meprobamate, and probably contribute to the abuse potential of this drug.

Drug Discrimination Studies for Investigations on the Mechanisms of Action of GABAB Receptor Ligands

This chapter will review several different drug discrimination procedures and discuss how they have been used to qualitatively and quantitatively study different components of a drug with a relatively simple mechanism of action (baclofen) and aDrug with a more complex mechanism ofaction [gamma-hydroxybutyrate (GHB)].

Elucidation of the Mechanism of Action of Carisoprodol at GABAA Receptors

In whole-cell patch clamp studies, carisoprodol allosterically modulated and directly activated human α1β2γ2 GABAAR function in a barbiturate-like manner and produced picrotoxin-sensitive, inward currents that were significantly larger than those produced by meprobamate, suggesting carisOProdol may directly produce GABAergic effects in the absence of GABA.

Assessment Of Pharmacists' And Patients' Knowledge And Attitude Towards Irrational Use Of Chlordiazepoxide-Clidinium Bromide Combination In Khartoum State

This study was conducted to evaluate the knowledge and attitude of community pharmacists in controlling Chlordiazepoxide-Clidinium bromide (CC) dispensing and to assess the potential of irrational

The irrational offering of benzodiazepines by medicine shops in Bangladesh: Recommends implementation of retail pharmacy as soon as possible

The offering of controlled drugs without the prescription was terrifyingly high by medicine shops in the Chittagong division of Bangladesh and the responsible authority should be taken steps to overcome this irrationality.

New benzodiazepines in Europe – a review

  • Art
  • 2021



Discriminative and reinforcing effects of brotizolam in rhesus monkeys

Results from the present experiment suggest that brotizolam would have pentobarbital-like subjective effects, however, the abuse liability of brotIZolam may be lower than that for diazepam.

Effects of chlordiazepoxide training dose on the mixed agonist-antagonist properties of benzodiazepine receptor antagonist Ro 15-1788, in a drug discrimination procedure

It is concluded that mixed agonist-antagonist properties are apparent after-variations of the BDZ training dose in a drug discrimination procedure, and the training dose effects on generalization and antagonism of Ro 15-1788 were not affected by the manner in which the lower CDP dose acquired drug stimulus control.

Discriminative stimulus effects of pentobarbital in pigeons

Pigeons were trained to discriminate the IM injection of pentobarbital from saline in a task in which 20 consecutive pecks on one of two response keys produced access to mixed grain, and narcotics such as morphine, ethylketazocine, cyclazocines, and SKF-10,047, at doses up to and including those that markedly suppressed response rates, produced responding predominantly on the saline-appropriate key.

Discriminative stimulus effects of diazepam in rats: evidence for a maximal effect.

  • H. ShannonS. Herling
  • Psychology, Biology
    The Journal of pharmacology and experimental therapeutics
  • 1983
It is demonstrated that the discrim inative effects of diazepam are qualitatively similar across this 20-fold range of training doses; quantitatively, the discriminative effects appear to reach a maximum and plateau above a training dose of 1.0 mg/kg in rats.

Discriminative stimulus properties of oxazepam in the pigeon.

Characteristics of pentobarbital discrimination in the gerbil: Transfer and antagonism

  • T. Järbe
  • Biology, Psychology
  • 2004
Reversing established discrimination does not necessarily mean that the same drug combination lacks discriminable effects as demonstrated in Experiment 2, although more slowly than gerbils trained with P-barb.

Discriminative stimulus effects of pentobarbital in rhesus monkeys: Tests of stimulus generalization and duration of action

The time-course of the discriminative stimulus effects of barbiturates in the rhesus monkey appears to parallel closely other pharmacological actions of these compounds.

Phencyclidine-like discriminative stimulus properties of opioids in the squirrel monkey

The PCP-like stimulus effects of certain opioids appear to be mediated at neuronal substrates acted upon by PCP rather than at sites typically associated with opiate activity, which may correspond to the sigma “opiate” receptor.

Discriminative-stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by Ro 15-1788.

  • R. Spealman
  • Psychology, Biology
    The Journal of pharmacology and experimental therapeutics
  • 1985
The benzodiazepines midazolam, chlordiazepoxide, diazepam and N-desmethyldiazepam, the cyclopyrrolone zopiclone and the triazolopyridazine CL 218,872 had qualitatively similar stimulus effects regardless of the type of consequence (food presentation or stimulus-shock termination) that maintained responding.