Effects of sesamin on primary human synovial fibroblasts and SW982 cell line induced by tumor necrosis factor-alpha as a synovitis-like model

@inproceedings{Khansai2017EffectsOS,
  title={Effects of sesamin on primary human synovial fibroblasts and SW982 cell line induced by tumor necrosis factor-alpha as a synovitis-like model},
  author={Manatsanan Khansai and Thanyaluck Phitak and Jeerawan Klangjorhor and Sasimol Udomrak and Kanda Fanhchaksai and Peraphan Pothacharoen and Prachya Kongtawelert},
  booktitle={BMC complementary and alternative medicine},
  year={2017}
}
BACKGROUND Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic synovitis, cartilage degradation and bone deformities. Synovitis is the term for inflammation of the synovial membrane, an early stage of RA. The pathogenesis of the disease occurs through cytokine induction. The major cytokine that increases the severity of RA is TNF-α. Thus, inhibition of the TNF-α cascade is an effective way to diminish the progression of the disease. We are interested in investigating the… CONTINUE READING

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