Effects of serotonin (5-HT)2 receptor ligands on depression-like behavior during nicotine withdrawal.

@article{Zaniewska2010EffectsOS,
  title={Effects of serotonin (5-HT)2 receptor ligands on depression-like behavior during nicotine withdrawal.},
  author={Magdalena Zaniewska and Andrew C McCreary and Karolina Wydra and Małgorzata Filip},
  journal={Neuropharmacology},
  year={2010},
  volume={58 7},
  pages={1140-6}
}
A pronounced withdrawal syndrome including depressed mood prevents cigarette smoking cessation. We tested if blockade or activation of serotonin (5-HT)(2) receptors affected the time of immobility (as an indirect measure of depression-like behavior) in naïve animals and in those withdrawn from chronic nicotine in the forced swim test (FST). The antidepressant imipramine was used as a control. In the FST, the selective 5-HT(2A) receptor antagonist M100,907 (1-2 mg/kg, but not 0.5 mg/kg), the… CONTINUE READING

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