Effects of serotonergic medications on locomotor performance in humans with incomplete spinal cord injury.

@article{Leech2014EffectsOS,
  title={Effects of serotonergic medications on locomotor performance in humans with incomplete spinal cord injury.},
  author={Kristan A Leech and Catherine R. Kinnaird and T. George Hornby},
  journal={Journal of neurotrauma},
  year={2014},
  volume={31 15},
  pages={1334-42}
}
Incomplete spinal cord injury (iSCI) often results in significant motor impairments that lead to decreased functional mobility. Loss of descending serotonergic (5HT) input to spinal circuits is thought to contribute to motor impairments, with enhanced motor function demonstrated through augmentation of 5HT signaling. However, the presence of spastic motor behaviors in SCI is attributed, in part, to changes in spinal 5HT receptors that augment their activity in the absence of 5HT, although data… CONTINUE READING