Effects of sequestration on signal transduction cascades.

@article{Blthgen2006EffectsOS,
  title={Effects of sequestration on signal transduction cascades.},
  author={Nils Bl{\"u}thgen and Frank J. Bruggeman and Stefan Legewie and Hanspeter Herzel and Hans Victor Westerhoff and Boris N. Kholodenko},
  journal={The FEBS journal},
  year={2006},
  volume={273 5},
  pages={
          895-906
        }
}
The building blocks of most signal transduction pathways are pairs of enzymes, such as kinases and phosphatases, that control the activity of protein targets by covalent modification. It has previously been shown [Goldbeter A & Koshland DE (1981) Proc Natl Acad Sci USA 78, 6840-6844] that these systems can be highly sensitive to changes in stimuli if their catalysing enzymes are saturated with their target protein substrates. This mechanism, termed zero-order ultrasensitivity, may set… CONTINUE READING
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