Effects of septal cholinergic lesion on rat exploratory behavior in an open-field.

@article{Lamprea2003EffectsOS,
  title={Effects of septal cholinergic lesion on rat exploratory behavior in an open-field.},
  author={Marisol Rodr{\'i}guez Lamprea and Fernando Parra Cardenas and Rodolfo Silveira and Thomas J. Walsh and Silvio Morato},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={2003},
  volume={36 2},
  pages={233-8}
}
The medial septum participates in the modulation of exploratory behavior triggered by novelty. Also, selective lesions of the cholinergic component of the septohippocampal system alter the habituation of rats to an elevated plus-maze without modifying anxiety indices. We investigated the effects of the intraseptal injection of the cholinergic immunotoxin 192 IgG-saporin (SAP) on the behavior of rats in an open-field. Thirty-nine male Wistar rats (weight: 194-230 g) were divided into three… CONTINUE READING

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