Effects of selenium, vitamin E and vitamin C on human prostacyclin and thromboxane synthesis in vitro.

@article{Toivanen1987EffectsOS,
  title={Effects of selenium, vitamin E and vitamin C on human prostacyclin and thromboxane synthesis in vitro.},
  author={J Toivanen},
  journal={Prostaglandins, leukotrienes, and medicine},
  year={1987},
  volume={26 3},
  pages={
          265-80
        }
}
  • J. Toivanen
  • Published 1 March 1987
  • Biology, Medicine, Chemistry
  • Prostaglandins, leukotrienes, and medicine
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Aspirin markedly reduces mucosal prostanoid concentrations in rats, without apparent effects on gastric injury, whereas vitamin E supplementation significantly reduced mucosal 6-keto-prostaglandin F(1 alpha) concentrations, Nevertheless, vitamin E supplements did not result in more gastric injuries in aspirin-treated rats than in controls.
A study of the putative anti-atherogenic mechanisms of Vitamin E and Vitamin C in subjects at coronary risk
TLDR
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an ulceropermissive effect of vitamin E. To assess the effect of vitamin E on aspirin-induced gastric injury and mucosal prostan
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Aspirin markedly reduces mucosal prostanoid concentra tions in rats, without apparent effects on gastric injury, whereas vitamin E supplementation significantly reduced mucosal 6-keto prostaglandin Fia concentrations.
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References

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THE EFFECTS OF VITAMIN E AND CORN OIL ON PROSTACYCLIN AND THROMBOXANE B2 SYNTHESIS IN RATS *
TLDR
The relationship between dietary vitamin E (VE) and corn oil (CO) on the synthesis of PGI, and TxA, in rats was investigated and PGI release, while invariably greater in animals fed 15% CO, was increased at the highest dietary VE level (1.000 ppm).
Differential effects of dietary vitamin E and antioxidants on eicosanoid synthesis in young rabbits.
TLDR
The data showed that dietary antioxidants selectively affect eicosanoid synthesis in different tissues, including prostacyclin synthesis in isolated aorta segments and perfused hearts and thromboxane synthesis in thrombin-stimulated washed platelets.
Effects of vitamin E and aspirin on the incidence of encephalomalacia, fatty acid status and serum thromboxane levels in chicks.
TLDR
It is unlikely that the development of NE is a result of thromboxane-mediated thrombosis, because the serum TxB2 levels in vitamin E--deficient versus vitamin E)--adequate chicks, unlike changes noted for rats, were decreased.
Vitamin E. An inhibitor of the platelet release reaction.
TLDR
The sharp rise in lipid peroxides normally associated with platelet aggregation was markedly reduced by alpha-tocopherol and also by acetylsalicylic acid, a known inhibitor of the platelet release reaction.
Protective effect of vitamin E on immune triggered, granulocyte mediated endothelial injury.
TLDR
It is concluded that vitamin E exerts a protective effect on immune triggered endothelial damage, partly by increasing the endogenous anti-oxidant potential, part by modulating intrinsic endothelial prostaglandin production.
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