Effects of selective sigma receptor ligands on glucocorticoid receptor-mediated gene transcription in LMCAT cells.

@article{Skuza2008EffectsOS,
  title={Effects of selective sigma receptor ligands on glucocorticoid receptor-mediated gene transcription in LMCAT cells.},
  author={Grażyna Skuza and Zofia Rog{\'o}ż and Magdalena Szymańska and Bogusława Budziszewska},
  journal={Pharmacological reports : PR},
  year={2008},
  volume={60 6},
  pages={889-95}
}
It has been shown previously that sigma receptor agonists reveal potential antidepressant activity in experimental models. Moreover, some data indicate sigma receptor contribution to stress-induced responses (e.g., conditioned fear stress in mice), though the mechanism by which sigma ligands can exert their effects, remains unclear. Recent studies have… CONTINUE READING