Effects of selective serotonin reuptake inhibitors on immobility time in the tail suspension test in streptozotocin-induced diabetic mice.

@article{Kamei2003EffectsOS,
  title={Effects of selective serotonin reuptake inhibitors on immobility time in the tail suspension test in streptozotocin-induced diabetic mice.},
  author={Junzo Kamei and Shigeo Miyata and Kayo Morita and Akiyoshi Saitoh and Hiroshi Takeda},
  journal={Pharmacology, biochemistry, and behavior},
  year={2003},
  volume={75 2},
  pages={247-54}
}
We examined the effects of fluoxetine and fluvoxamine, selective serotonin reuptake inhibitors (SSRIs), and desipramine, a selective noradrenaline (NA) reuptake inhibitor, given alone or in combination with diazepam on immobility time in the tail suspension test in diabetic mice. Immobility time was significantly longer in diabetic than in nondiabetic mice. Diazepam (0.1 and 0.3 mg/kg s.c.) dose-dependently decreased immobility time in diabetic mice to the level observed in saline-treated… CONTINUE READING