Effects of selective monoamine oxidase inhibitors on the in vivo release and metabolism of dopamine in the rat striatum.

@article{Butcher1990EffectsOS,
  title={Effects of selective monoamine oxidase inhibitors on the in vivo release and metabolism of dopamine in the rat striatum.},
  author={Steven P. Butcher and I S Fairbrother and John B. Kelly and Gordon W. Arbuthnott},
  journal={Journal of neurochemistry},
  year={1990},
  volume={55 3},
  pages={981-8}
}
Brain microdialysis was used to examine the in vivo efflux and metabolism of dopamine (DA) in the rat striatum following monoamine oxidase (MAO) inhibition. Relevant catecholamines and indoleamines were quantified by HPLC coupled with a electrochemical detection system. The MAO-B inhibitor selegiline only affected DA deamination at a dose shown to inhibit partially type A MAO. Alterations in DA and metabolite efflux were not observed when using the MAO-B-selective dose of 1 mg/kg of selegiline… CONTINUE READING

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