Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors

@article{Schlicker1997EffectsOS,
  title={Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors},
  author={Eberhard Schlicker and Klaus Fink and Gerhard J Molderings and Gary W Price and Malcolm Duckworth and Laramie M. Gaster and Derek N. Middlemiss and J. Zentner and James Anthony Likungu and Manfred G{\"o}thert},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1997},
  volume={356},
  pages={321-327}
}
Human cerebral cortical slices and synaptosomes, guinea-pig cerebral cortical slices and human right atrial appendages were used to study the effects of SB-216641, a preferential h5-HT1B receptor ligand, and of BRL-15572, a preferential h5-HT1D receptor ligand, on the presynaptic h5-HT1B and h5-HT1B-like autoreceptors in the human and guinea-pig brain preparations, respectively, and on the presynaptic h5-HT1D heteroreceptors in the human atrium. The brain preparations, preincubated with [3H… CONTINUE READING