Effects of selective endothelin ET(A) receptor antagonists on endothelin-1-induced potentiation of cancer pain.

@article{Yuyama2004EffectsOS,
  title={Effects of selective endothelin ET(A) receptor antagonists on endothelin-1-induced potentiation of cancer pain.},
  author={Hironori Yuyama and Akiko Koakutsu and Noriko Fujiyasu and Masayuki Tanahashi and Akira Fujimori and Shuichi Sato and Kumiko Shibasaki and Shohei Tanaka and Katsumi Sudoh and Masao Sasamata and Keiji Miyata},
  journal={European journal of pharmacology},
  year={2004},
  volume={492 2-3},
  pages={
          177-82
        }
}
  • Hironori Yuyama, Akiko Koakutsu, +8 authors Keiji Miyata
  • Published in
    European journal of…
    2004
  • Medicine
  • In some diseases in which endothelin-1 production increases, e.g. prostate cancer, endothelin-1 is considered to be involved in the generation of pain. In the present study, we investigated the effects of a selective endothelin ET(A) receptor antagonist, (E)-N-[6-methoxy-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-2-phenylethenesulfonamide monopotassium salt (YM598), on the nociception potentiated by endothelin-1 in a cancer inoculation-induced pain model in mice, induced by inoculation of the… CONTINUE READING

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