Effects of selective dopamine D4 receptor antagonist, L-741,741, on sleep and wakefulness in the rat

@article{Cavas2006EffectsOS,
  title={Effects of selective dopamine D4 receptor antagonist, L-741,741, on sleep and wakefulness in the rat},
  author={Mar{\'i}a Cavas and Jos{\'e} Francisco Navarro},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2006},
  volume={30},
  pages={668-678}
}
The influence of the dopamine system upon sleep/wake states is not fully understood. To date, the role of dopamine D4 receptor has not been studied. The aim of this work is to study the influence of dopamine D4 receptor upon sleep/wake states in male rats. Male Wistar rats were implanted with electroencephalography and electromyography electrodes for sleep recording. Sleep/wake times were compared in rats first treated with control solution (vehicle) and the day after treated with a potent and… CONTINUE READING

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