Effects of selective central muscarinic blockade on schedule-controlled behavior and on the rate-decreasing effects of physostigmine

@article{Hymowitz1984EffectsOS,
  title={Effects of selective central muscarinic blockade on schedule-controlled behavior and on the rate-decreasing effects of physostigmine},
  author={N. Hymowitz and H. Brezenoff},
  journal={Pharmacology Biochemistry and Behavior},
  year={1984},
  volume={21},
  pages={109-115}
}
  • N. Hymowitz, H. Brezenoff
  • Published 1984
  • Chemistry, Medicine
  • Pharmacology Biochemistry and Behavior
  • N-(4-diethylamino-2-butynyl)-succinimide, or DKJ-21, is a muscarinic receptor antagonist with a high degree of selectivity for the central nervous system. In the present study of 6 rats maintained under a fixed-interval 50-sec schedule of food reinforcement, atropine and methylatropine reduced responding in a dose dependent manner, while DKJ-21 had little or no effect. Our findings suggest that the suppression caused by atropine and methylatropine may be the result of the dry mouth induced by… CONTINUE READING
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