Effects of selaginellin on homocysteine-induced senescence in human umbilical vein endothelial cells.

@article{Wang2010EffectsOS,
  title={Effects of selaginellin on homocysteine-induced senescence in human umbilical vein endothelial cells.},
  author={Chen-Jing Wang and Chang-ping Hu and Kang-ping Xu and Gui-Shan Tan and Yuanjian Li},
  journal={Journal of cardiovascular pharmacology},
  year={2010},
  volume={55 6},
  pages={560-6}
}
Homocysteine plays a key role in endothelial cell senescence associated with atherosclerosis-based cardiovascular diseases. Selaginellin, a component extracted from Selaginella pulvinata (Hook. et Grev.) Maximo, was assessed for its ability to protect human umbilical vein endothelial cells against homocysteine-induced senescence. The endothelial cells were pretreated with various concentrations (10(-7), 3 x 10(-7), or 10(-6) M) of selaginellin for 1 hour before exposure to homocysteine… CONTINUE READING