Corpus ID: 43490370

Effects of secretin on the normal and pathological beta-cell.

  title={Effects of secretin on the normal and pathological beta-cell.},
  author={B. Glaser and B. Shapiro and J. Glowniak and S. Fajans and A. Vinik},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={66 6},
Secretin is a gastrointestinal hormone that stimulates insulin secretion and enhances the insulin response to glucose. The mechanism by which secretin acts on the beta-cell has not been extensively studied. The plasma insulin responses to secretin (2 U/kg), expressed as the percent increase relative to basal plasma insulin concentrations, were similar in normal (n = 23) and obese subjects with normal glucose tolerance (n = 12), but were decreased in obese subjects with abnormal glucose… Expand
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