Effects of seasonal acclimatization on action potentials and sarcolemmal K+ currents in roach (Rutilus rutilus) cardiac myocytes.

@article{Badr2017EffectsOS,
  title={Effects of seasonal acclimatization on action potentials and sarcolemmal K+ currents in roach (Rutilus rutilus) cardiac myocytes.},
  author={Ahmed Badr and Minna Hassinen and Mohamed Abdel-Fattah El-Sayed and Matti Vornanen},
  journal={Comparative biochemistry and physiology. Part A, Molecular \& integrative physiology},
  year={2017},
  volume={205},
  pages={
          15-27
        }
}
  • A. Badr, M. Hassinen, +1 author M. Vornanen
  • Published 1 March 2017
  • Biology, Medicine
  • Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
Temperature sensitivity of electrical excitability is a potential limiting factor for high temperature tolerance of ectotherms. The present study examines whether heat resistance of electrical excitability of cardiac myocytes is modified by seasonal thermal acclimatization in roach (Rutilus rutilus), a eurythermal teleost species. To this end, temperature dependencies of ventricular action potentials (APs), and atrial and ventricular K+ currents were measured from winter-acclimatized (WiR) and… Expand
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Effects of seasonal acclimatization on thermal tolerance of inward currents in roach (Rutilus rutilus) cardiac myocytes
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The response of sodium (INa) and calcium (ICa) currents in heat tolerance of cardiac excitability was examined in a eurythermic fish and the response of INa to seasonal acclimatization conforms to the TDEE hypothesis. Expand
Electrical excitability of roach ( Rutilus rutilus) ventricular myocytes: effects of extracellular K+, temperature, and pacing frequency.
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Although high [K+]o antagonizes the negative effects of high temperature on excitation threshold, the precipitous depression of the rate of AP upstroke and complete loss of excitability in some myocytes suggest that the combination of highTemperature and high [ K+]O will severely impair ventricular excitabilityIn roach. Expand
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The effects of seasonal acclimatization on cardiac responses to low temperatures are stronger than those of acclimation to similar temperatures in laboratory conditions, highlighting the importance of seasonal cues for cardiac remodelling in a eurythermal fish. Expand
Repolarizing potassium currents in working myocardium of Japanese quail: Novel translational model for cardiac electrophysiology.
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The described pattern of repolarizing ionic currents and channels in quail myocardium makes this species a novel and suitable experimental model for translational cardiac research and reveals new information related to the evolution of cardiac electrophysiology in vertebrates. Expand
Small functional If current in sinoatrial pacemaker cells of the brown trout (Salmo trutta fario) heart despite strong expression of HCN channel transcripts.
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The results strongly suggest that fH regulation in the brown trout heart is largely independent on If, and the presence and activity of HCN channels in the SA pacemaker cells and their putative role in heart rate regulation is examined. Expand
Transcript expression of inward rectifier potassium channels of Kir2 subfamily in Arctic marine and freshwater fish species
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The cardiac Kir2 composition seems to be dependent on both phylogenetic position and thermal preference of the fish. Expand
Electrical Excitability of the Fish Heart and Its Autonomic Regulation
TLDR
This chapter reviews the current state of knowledge on electrical excitability of the fish heart, with a major emphasis on the recent advances in the authors' understanding of ion currents in fish cardiac myocytes, their molecular basis, and their regulation by the autonomic nervous system. Expand
Feeling the heat: source–sink mismatch as a mechanism underlying the failure of thermal tolerance
  • M. Vornanen
  • Chemistry, Medicine
  • Journal of Experimental Biology
  • 2020
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A modified hypothesis about high temperature-induced failure of electrically excitable tissues is discussed, and can explain a number of heat-induced effects, including reduced heart rate, reduced synaptic transmission between neurons and reduced impulse transfer from neurons to muscles. Expand
Temperature and the Cardiovascular System
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The suggestion that cardiac function could be a key factor determining the distribution of fishes is investigated, by specifically investigating the idea that mitochondrial (tissue) oxygen demand increases as temperatures warm, which influences the cardiovascular system's critical role in supporting aerobic metabolism. Expand
Plasma potassium ranges associated with mortality across stages of chronic kidney disease: the Stockholm CREAtinine Measurements (SCREAM) project
  • Alessandro Gasparini, M. Evans, +5 authors J. Carrero
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2018
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The view that hyperkalaemia is better tolerated with worse CKD, it challenges the current use of a single optimal K+ range for all patients and modifies K+ distribution and the ranges that predict mortality in the community. Expand
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